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By 12 months off medication, most research participants have regained 60 to 70 percent of the weight they lost

The authors noted, ...semaglutide was superior to placebo for MACE reduction at all levels of baseline weight or waist circumference from early in the study. Here is a gift link to a New York Times article about this study

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Participants: Participants were triplets, 2 male children and 1 female, and their parents